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Large-Capacity Reach-In CO₂ Incubator

Culture large volumes of patient samples for bacterial growth, perform short-term growth studies and work with large volume products. The Thermo ScientificTM Large-Capacity Reach-In CO2 Incubator offers a broad range of built-in features that provide optimal flexibility. This unit provides elevated RH to prevent product desiccation in medium-term cultures and maintains temperature uniformity, even when equipment (cell rollers, rockers, shakers, spinners, stirrers) is installed in the chamber.

Overview

Overview

CO2 Sensor: TC Sensor; Temperature Range: Ambient +5°C to 50°C

Culture large volumes of patient samples for bacterial growth, perform short-term growth studies and work with large volume products. The Thermo ScientificTM Large-Capacity Reach-In CO2 Incubator offers a broad range of built-in features that provide optimal flexibility. This unit provides elevated RH to prevent product desiccation in medium-term cultures and maintains temperature uniformity, even when equipment (cell rollers, rockers, shakers, spinners, stirrers) is installed in the chamber.

Performance

  • Directed horizontal laminar airflow system promotes ideal growth environment
  • Three RH system settings: off, medium, high
  • Three water fill options: automatic, semi-automatic, ergonomic manual
  • Thermo Scientific™ Enviro-Scan™ microprocessor control
  • Selectable temperature, overtemperature, CO2, humidity
  • Audible/visual alarm and alarm silence
  • Remote alarm contacts
  • Data outputs to help meet internal and regulatory documentation requirements

Construction

  • Heated triple-pane glass door minimizes condensation and permits a clear view
  • Two thru-wall access ports (one on right and left sidewalls) for probes, sensors, power cords
  • Interior and exterior accessory receptacles
  • Stainless-steel interior
  • Heavy-duty, solid stainless-steel shelves resist corrosion; adjust on 2″ (5.1cm) centers
  • Swivel, locking casters ensure easy mobility for installation and cleaning
  • Leveling feet provide stability for added safety in the lab

Compatible with:

  • Built-in gas guards (1900000, 190642, 1900086, 190640)
  • Factory-installed data outputs (190544, 190523, 1900085, 190512, 190543, 1900152)
  • Two-stage gas regulators (965010, 961027)
  • Shelves (227642, 224139, 502045, 227641, 224155)

Recommended for:

  • Culturing large volumes of patient samples for bacterial growth
  • Performing short-term growth studies
  • Working with large volume products

Advanced CO₂ Incubation

Embark on the remarkable

Advanced incubation solutions enable the creation of novel cultures and therapies. Our most innovative CO2 Incubators offer designs that support groundbreaking science including: automated technologies, GMP and cleanroom requirements, and scale-up processes. View the comparison chart below to explore the features of all of our advanced CO2 incubators.

Designed for integration into automated laboratories

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Thermo Scientific Vios iDx AD 255 CO2 Incubators are designed for integration into automated laboratories that leverage a modular design to scale. The VIOS family of incubators are known for optimal cell growth conditions and minimal contamination risk. With the added innovation of a patent-pending automated door control, these leading incubators now bring their excellent recovery and uniformity to emerging automated cell therapy production processes 24/7, 365.

Many industry experts agree that human handling and complex processes limit broader application of cutting-edge cell therapies to treat cancer, autoimmunity, and orphan diseases. As automation is incorporated across the sector, these treatments can be produced in a more cost effective way. Several companies are developing advanced robotics to help meet these goals and Heracell VIOS 250i AxD CO2 Incubators are a natural fit. Various therapies are researched and developed in these incubators due to their excellent culturing conditions that help ensure important cellular critical quality attributes.

Cleanroom compatible CO₂ incubators

Thermo Scientific Vios iDx CR CO2 Incubators are third-party certified cleanroom compatible and suitable for ISO Class 5 and Good Manufacturing Practices (GMP) grade A/B environments. They feature an active particle control system and demonstrated compatibility with commonly used cleanroom cleaning methods, making it the exceptional fit for your cleanroom suite or GMP production environment.

Download our ebook Five Reasons to choose a cleanroom CO2 incubator that is certified compatible for an in-depth look at the advantages of using a CO2 incubator with cleanroom certification.

Features of
all cleanroom compatible incubators

Cleanroom certified

Through rigorous testing, the Vios iDx CR CO2 incubators have successfully achieved ISO class 5 compatibility for the considered particle sizes in both standard operating and sterilization modes.

Robust and easy to clean

  • Brushed 304 stainless steel exterior is compatible with STERIS dry non-condensing VHP and 3% manual wipe hydrogen peroxide cleaning methods typically used in cleanroom environments.
  • Sealed exterior casing includes silicone sealed electronics and welded door to contain any particulate risk.
  • IP54 rated componentry protects electronics from dust and is resistant to water spray from any direction.

Documentation package including:

  • Regulatory certificates
  • Declaration of Conformity (CE) with EU law, CSA and QMS Certificates
  • Recommended protocols
  • User-replaceable parts and consumables lists
  • Product-specific factory documentation and specification
  • Certificates of conformance, calibration, and technical specifications
  • 3rd party certificate of compatibility with ISO Class 5 and GMP Grade A/B cleanroom environments

Advanced CO2 Incubators Comparison

View all CO2 incubator specifications with the CO2 incubator selection guide

Scale-up with CultiMaxx Shelving Systems

As you scale out your cell therapy manufacturing, the incubator you have come to trust can now adjust with you. To match your changing needs, our special shelving system options offer additional capacity and/or improved access for specialized cell culture vessels such as Wilson Wolf G-Rex® 500M-CS bioreactors or Thermo Scientific Nunc Cell Factory systems.

These dedicated shelving systems are available as separate accessories. Each offers several advantages as you enter the cell expansion stage using larger cell culture vessels.

View options for Vios iDx CR, Steri-Cult, and Large Capacity Reach-In CO2 incubators

CultiMaxx Shelving for G-Rex Bioreactors, Nunc Cell Factory Systems and 1 L Culture Bags in Vios iDx CO2 Incubators.

Specifications

Large-Capacity Reach-In CO2 Incubator, 821 L, Polished Stainless Steel (Cat. No. 3951)

Capacity (English) 29 cu. ft.
Capacity (Metric) 821 L
Certifications/Compliance UL, cUL, CE, Class I Medical Device
Chamber Material Polished Stainless Steel
CO2 Concentration Range 0 to 20%
CO2 Sensor Technology TC Sensor
Convection Type Air-jacketed
Data Outputs Optional 4-20mA
Description Single 821L incubator
Dimensions (D x W x H) Interior 27 x 31 x 60 in. (68.5 x 78.7 x 152.4 cm)
Dimensions (L x W x H) 33 x 38 x 80 in. (83.8 x 96.5 x 203.2 cm)
Electrical Requirements 200/230 V, 50/60 Hz
Humidity Source 15L integrated humidity reservoir
Lighting LED
Material Stainless Steel
No. of Places 22
No. of Shelves 5 std./22 max.
Oxygen Control None
Relative Humidity 80%
Temperature Range (Metric) Ambient +5° to 50°C
Type CO2 Incubator
Unit Size Each
Voltage 200/230 V
Weight (English) 500 lb.

Available models

Vios iDx AD 255 CO2 Incubator
Automated operation of incubator door Simplified door design, well suited for robotic interface Automatic stop if an obstruction is encountered Patented Thermo Scientific THRIVE active airflow technology for homogenous growth conditions Remote control and foot pedal configurations for assisted door opening available Integration-ready for automated production settings that leverage a modular design to scale Built with all benefits of Vios iDx 255 CO2 Incubators with additional configurations available

Available models

Vios iDx CR 165 CO2 Incubator – CTS SeriesVios iDx CR 255 CO2 Incubator – CTS SeriesForma Steri-Cult CO2 Incubator – CTS SeriesLarge-Capacity Reach-In CO2 IncubatorVios iDx AD 255 CO2 Incubator
Specialized features
Certified cleanroom compatible, ISO Class 5, GMP Grade A/B environments, FAT documentation package included Largest capacity stackable option, FAT documentation package Largest capacity CO2 incubator option Automated door for continuous hands-free operation
Individual chamber volume
165 L 255 L 232 L or 323 L 821 L 255L
Chamber material
Brushed stainless steel exterior casing with IP54 compliance Powder-coated cold-rolled steel Powder-coated cold-rolled steel or optional brushed stainless steel
Sensors
IR180SI IR180Si IR180Si TC180 IR180Si
Sterilization
Steri-Run High-Temperature Sterilization Cycle 140 ° Sterilization Cycle -- Steri-Run High-Temperature Sterilization Cycle
Oxygen control
1 – 21 %, 5 – 90 % optional -- -- 1 – 21 %
Relative humidity
>93 % at 37 °C 95 %, Controllable <80 %, High <90 % >93 % at 37 °C
Filtration
Interior HEPA filter for ISO Class 5 chamber conditions, exterior HEPA filter to particulate control Interior HEPA filter for ISO Class 5 chamber conditions Interior HEPA filter for ISO Class 5 chamber conditions
Data and connectivity
USB, 4-20mA, Thermo Scientific Connect Edge, and OPC-UA Gateway for 21 CFR Part 11-compliance and GMP needs Optional 4-20mA Optional 4-20mA USB, 4-20mA, Thermo Scientific Connect Edge, and OPC-UA Gateway for 21 CFR Part 11-compliance and GMP needs
Stacking options
Stack two incubators by combining the desired two incubators with:   Cleanroom 165 L low-profile roller base Cleanroom 165 L stacking adapter Stack two incubators by combining the desired two incubators with:   Cleanroom 255 L low-profile roller base Cleanroom 255 L stacking adapter Speak to a specialist about your requirements. -- Speak to a specialist about your requirements.

Available models

Shelving SystemVessel TypeAdvantagesAction
CultiMaxx shelving system for 1 L cell culture bags Up to 2.5x more culture bag capacity per incubator and increased exposure to promote better gas exchange Buy now ›
CultiMaxx shelving system for 10x Nunc Cell Factory 4-layer systems Accommodates 1 more Cell Factory system, easy access, improved clearance for air filters Buy now ›
CultiMaxx shelving system for 6x Nunc Cell Factory 10- or 13- systems Easy access, better clearance for air filter Buy now ›
CultiMaxx shelving system for up to 10x G-Rex® 500M-CS (or up to 45x 100M-CS or 123x 10M-CS) 150% more capacity compared to standard shelving Buy now ›

Documents

Videos

Large-Capacity Reach-In CO₂ Incubator – video

Product information, images, documents and videos: Thermo Fisher Scientific. View on manufacturer website Source 2